Protein Purification And Isolation Market Size | Companies
The global protein purification and isolation market size was exhibited at USD 9.55 billion in 2023 and is projected to hit around USD 26.82 billion by 2033, growing at a CAGR of 10.88% during the forecast period 2024 to 2033.
| Report Coverage | Details |
| Market Size in 2024 | USD 10.59 Billion |
| Market Size by 2033 | USD 26.82 Billion |
| Growth Rate From 2024 to 2033 | CAGR of 10.88% |
| Base Year | 2023 |
| Forecast Period | 2024-2033 |
| Segments Covered | Product, Technology, Application, End-use, Region |
| Market Analysis (Terms Used) | Value (US$ Million/Billion) or (Volume/Units) |
| Regional scope | North America; Europe; Asia Pacific; Latin America; Middle East & Africa |
| Key Companies Profiled | Thermo Fisher Scientific, Inc.; Merck KGaA; QIAGEN N.V; Bio-Rad Laboratories, Inc.; Agilent Technologies; GE Healthcare; Promega Corporation; Norgen Biotek Corp.; Abcam plc; Danaher |
Growing research in the areas of pharmaceutical and biotechnology for the development of novel drugs drives the demand for protein purification and isolation. Furthermore, rising investments in R&D by pharmaceutical manufacturers are projected to drive market growth. The unexpected outbreak of the COVID-19 pandemic prompted the implementation of lockdown rules across the globe, causing delays in protein purification and isolation import and export. The pandemic also lowered the availability of funds from private investors and governments around the world. Purification and isolation of proteins refer to a set of procedures for isolating a specific protein from a complicated combination of cells, organisms, or tissues.
Protein research requires these techniques to separate, concentrate, stabilize, and eliminate contaminants including endotoxins, viruses, and nucleic acid. They involve determining material and maintaining a purification table to track the enzyme's development. They are mostly used to classify a protein's function, structure, and interactions. Affinity chromatography, immunoprecipitation, proteomics, and enzyme assay are some of the regularly utilized methods of protein purification and separation. Over the pandemic, the disruption in the process had a negative impact on the protein purification & isolation market, but increased government funding for R&D is enabling the market to recover, and the market is expected to grow during the forecast period.
Governments are increasingly investing in R&D and undertaking initiatives that promote the development and growth of pharmaceutical and biotechnology markets. They also provided added benefits via tax incentives, grants, and investment-friendly regulations among others. Pharmaceutical is a highly lucrative industry for protein purification and isolation solutions owing to significant investments for the development of biomarker specific molecules. Precise isolation of proteins with a significant amount of purified substrate is a vital component of the preclinical drug development phase.
Ongoing technological advancements further drive the market for protein purification and isolation solutions. Magnetic and protein beads and ligand tagging systems are increasingly preferred over traditional methods such as agarose beads and other resins. Furthermore, the rising usage of automated analyzers is projected to drive the demand for purification and isolation solutions.
The rising significance of discovering novel ligands, such as protein-based therapeutic compounds, is a major factor driving market expansion. Additionally, rising demand for purification kits in rapid screen tests, a shift towards technologically advanced instrumentation for protein purification, growth of the proteomics market, and increasing R&D in pharmaceutical and biotechnological fields are expected to propel protein purification and isolation market forward. However, instruments that result in a reduced acceptance rate and the difficulty of maintaining purification kits that fit all proposes are market restraints, and high tool costs are a hurdle for market growth. In addition, the protein purification and isolation industry are benefiting from untapped growth markets and protein therapies.
Based on products, the market is categorized into consumables and instruments. The consumables segment dominated the market in 2023 with a share of 61.39%. Columns, reagents, kits, resins, and magnetic beads are the most commonly used consumables. In 2023, the kits segment dominated the consumables product segment as they are convenient and offer several benefits. For instance, they can be effectively used for the isolation of GST-tagged protein from the crude or cleared lysate.
The instruments segment is projected to witness a CAGR of 9.76% over the forecast period due to the development of accurate, sensitive, and portable instruments. Furthermore, the growth of the instruments segment can be attributed to the high usage and a rise in the commercialization of advanced equipment for protein analysis that ensure precise results.
Chromatography was the largest revenue-generating segment in 2023 and held a market share of 29.16%. Chromatography is one of the most accurate and sensitive techniques for the isolation and purification of proteins when compared to its counterparts. Various companies are hence focusing on commercializing new products based on this technology in order to expand their product portfolio.
For instance, in 2018, Bio-Rad commercialized ChromLab Software, a novel software for the purification of proteins using NGC chromatography systems. The various types of chromatography techniques available make them suitable for a range of applications, further driving the segment growth.
Protein-protein interaction was the largest revenue-generating application segment in 2023 with a share of 32.17% and is projected to witness substantial growth over the forecast period. High adoption of these techniques for deriving highly purified proteins and an increasing number of studies based on structural protein is contributing to the segment growth.
The drug screening segment is estimated to witness the highest CAGR of 11.61% from 2024 to 2033. It is extensively used for discovering innovative drugs with different applications. Drug screening comprises the development of drugs with higher efficacy than conventional drugs as well as fewer side effects. Moreover, increasing R&D investments by manufacturers for the screening of novel drugs through structure-based studies and protein-protein interaction is projected to drive the segment growth.
On the basis of end-use, the market for protein purification and isolation has been segmented into academic and research institutes, hospitals, contract research organizations (CROs), and pharmaceutical and biotechnological companies. Academic and research institutes held the largest share of 40.26% in 2023. Growing research initiatives in academic institutes for structural and functional proteomics, detailed kinetic analysis, and protein-protein interaction are some of the factors contributing to the demand for protein purification and isolation solutions.
On the other hand, CROs are estimated to witness a CAGR of 11.35% over the forecast periodowing to the rise in the number of preclinical trials outsourced by drug development companies and significant R&D investments associated with it. These organizations conduct more precise R&D functions for the pharmaceutical industry, along with offering a range of services for clinical trial activities, further driving the segment growth over the forecast period.
On the basis of region, the market for protein purification and isolation is categorized into North America, Europe, Asia Pacific, Latin America, and Middle East and Africa. North America was the largest revenue-generating region and accounted for 47.20% market share in 2023. North America dominated the market owing to high funding for life science research, established research infrastructure, and the presence of key players. Furthermore, the rise in biopharmaceutical drug development is estimated to drive the growth of the regional market over the forecast period.
Asia Pacific is estimated to witness the fastest CAGR of 11.83% over the forecast period. Initiatives undertaken by governments of developing countries such as India and China for the development of healthcare infrastructure is estimated to drive the demand for protein purification and isolation solutions in this region. Moreover, these governments are providing funds for the development of novel purification and isolation methods.
This report forecasts revenue growth at country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2021 to 2033. For this study, Nova one advisor, Inc. has segmented the global protein purification and isolation market
Product
Technology
Application
End-use
Regional
Chapter 1 Methodology and Scope
1.1. Information Procurement
1.2. Information Or Data Analysis
1.3. Market Scope & Segment Definition
1.4. Market Model
1.4.1. Market Study, By Company Market Share
1.4.2. Regional Analysis
Chapter 2 Executive Summary
2.1. Market Snapshot
2.2. Segment Snapshot
2.3. Competitive Landscape Snapshot
Chapter 3 Market Variables, Trends & Scope
3.1. Market Lineage Outlook
3.1.1. Parent Market Outlook
3.1.2. Related/Ancillary Market Outlook
3.2. Market Dynamics
3.2.1. Market Driver Analysis
3.2.1.1. Increase In Investment In Pharmaceutical And Biotechnological R&D
3.2.1.2. Growing Need For More Accurate And Rapid Purification Kits
3.2.1.3. Technological Advancements In Protein Purification And Isolation Techniques
3.2.2. Market Restraint Analysis
3.2.2.1. High Cost Of Purification Instruments And Lack Of Skilled Professionals Industry Analysis Tools
3.2.3. Porter’s Five Forces Analysis
3.2.4. PESTEL Analysis
3.2.5. COVID-19 Impact Analysis
Chapter 4 Products Business Analysis
4.1 Protein Purification And Isolation Market: Product Movement Analysis
4.2 Instruments
4.2.1 Instruments Market, 2021 - 2033 (USD Million)
4.3 Consumables
4.3.1 Consumables Market, 2021 - 2033 (USD Million)
4.3.2 Kits
4.3.2.1 Kits Market, 2021 - 2033 (USD Million)
4.3.3 Reagents
4.3.3.1 Reagents Market, 2021 - 2033 (USD Million)
4.3.4 Columns
4.3.4.1 Columns Market, 2021 - 2033 (USD Million)
4.3.5 Magnetic Beads
4.3.5.1 Magnetic Beads Market, 2021 - 2033 (USD Million)
4.3.6 Resins
4.3.6.1 Resins Market, 2021 - 2033 (USD Million)
4.3.7 Others
4.3.7.1 Other Consumables Market, 2021 - 2033 (USD Million)
Chapter 5 Technology Business Analysis
5.1 Protein Purification And Isolation Market: Technology Movement Analysis
5.2 Ultrafiltration
5.2.1 Ultrafiltration Market, 2021 - 2033 (USD Million)
5.3 Precipitation
5.3.1 Precipitation Market, 2021 - 2033 (USD Million)
5.4 Chromatography
5.4.1 Chromatography Market, 2021 - 2033 (USD Million)
5.4.2 Ion Exchange Chromatography
5.4.2.1 Ion Exchange Chromatography Market, 2021 - 2033 (USD Million)
5.4.3 Affinity Chromatography
5.4.3.1 Affinity Chromatography Market, 2021 - 2033 (USD Million)
5.4.4 Reversed Phase Chromatography
5.4.4.1 Reversed Phase Chromatography Market, 2021 - 2033 (USD Million)
5.4.5 Size Exclusion Chromatography
5.4.5.1 Size Exclusion Chromatography Market, 2021 - 2033 (USD Million)
5.4.6 Hydrophobic Interaction Chromatography (HIC)
5.4.6.1 Hydrophobic Interaction Chromatography Market, 2021 - 2033 (USD Million)
5.5 Electrophoresis
5.5.1 Electrophoresis Market, 2021 - 2033 (USD Million)
5.5.2 Gel Electrophoresis
5.5.2.1 Gel Electrophoresis Market, 2021 - 2033 (USD Million)
5.5.3 Isoelectric Focusing (IEF)
5.5.3.1 Isoelectric Focusing (IEF) Market, 2021 - 2033 (USD Million)
5.5.4 Capillary Electrophoresis
5.5.4.1 Capillary Electrophoresis Market, 2021 - 2033 (USD Million)
5.6 Western Blotting
5.6.1 Western Blotting Market, 2021 - 2033 (USD Million)
5.7 Others
5.7.1 Other Technologies Market, 2021 - 2033 (USD Million)
Chapter 6 Application Business Analysis
6.1 Protein Purification And Isolation Market: Application Movement Analysis
6.2 Drug Screening
6.2.1 Drug Screening Market, 2016 - 2030 (USD Million)
6.3 Biomarker Discovery
6.3.1 Biomarker Discovery Market, 2016 - 2030 (USD Million)
6.4 Protein-Protein Interaction Studies
6.4.1 Protein-Protein Interaction Studies Market, 2016 - 2030 (USD Million)
6.5 Diagnostics
6.5.1 Diagnostics Market, 2016 - 2030 (USD Million)
Chapter 7 End Use Business Analysis
7.1 Protein Purification And Isolation Market: End Use Movement Analysis
7.2 Academic And Research Institutes
7.2.1 Academic And Research Institutes Market, 2021 - 2033 (USD Million)
7.3 Hospitals
7.3.1 Hospitals Market, 2021 - 2033 (USD Million)
7.4 Pharmaceutical And Biotechnological Companies
7.4.1 Pharmaceutical And Biotechnological Companies Market, 2021 - 2033 (USD Million)
7.5 CROs
7.5.1 CROs Market, 2021 - 2033 (USD Million)
Chapter 8 Regional Business Analysis
8.1. Protein Purification And Isolation Market Share By Region, 2024 & 2033
8.2. North America
8.2.1. SWOT Analysis
8.2.2. North America Protein Purification And Isolation Market, 2021 - 2033 (USD Million)
8.2.3. U.S.
8.2.3.1. Key Country Dynamics
8.2.3.2. Target Disease Prevalence
8.2.3.3. Competitive Scenario
8.2.3.4. U.S. Protein Purification And Isolation Market, 2021 - 2033 (USD Million)
8.2.4. Canada
8.2.4.1. Key Country Dynamics
8.2.4.2. Target Disease Prevalence
8.2.4.3. Competitive Scenario
8.2.4.4. Canada Protein Purification And Isolation Market, 2021 - 2033 (USD Million)
8.3. Europe
8.3.1. SWOT Analysis
8.3.2. Europe Protein Purification And Isolation Market, 2021 - 2033 (USD Million)
8.3.3. UK
8.3.3.1. Key Country Dynamics
8.3.3.2. Target Disease Prevalence
8.3.3.3. Competitive Scenario
8.3.3.4. UK Protein Purification And Isolation Market, 2021 - 2033 (USD Million)
8.3.4. Germany
8.3.4.1. Key Country Dynamics
8.3.4.2. Target Disease Prevalence
8.3.4.3. Competitive Scenario
8.3.4.4. Germany Protein Purification And Isolation Market, 2021 - 2033 (USD Million)
8.3.5. France
8.3.5.1. Key Country Dynamics
8.3.5.2. Target Disease Prevalence
8.3.5.3. Competitive Scenario
8.3.5.4. France Protein Purification And Isolation Market, 2021 - 2033 (USD Million)
8.3.6. Italy
8.3.6.1. Key Country Dynamics
8.3.6.2. Target Disease Prevalence
8.3.6.3. Competitive Scenario
8.3.6.4. Italy Protein Purification And Isolation Market, 2021 - 2033 (USD Million)
8.3.7. Spain
8.3.7.1. Key Country Dynamics
8.3.7.2. Target Disease Prevalence
8.3.7.3. Competitive Scenario
8.3.7.4. Spain Protein Purification And Isolation Market, 2021 - 2033 (USD Million)
8.3.8. Denmark
8.3.8.1. Key Country Dynamics
8.3.8.2. Target Disease Prevalence
8.3.8.3. Competitive Scenario
8.3.8.4. Denmark Protein Purification And Isolation Market, 2021 - 2033 (USD Million)
8.3.9. Sweden
8.3.9.1. Key Country Dynamics
8.3.9.2. Target Disease Prevalence
8.3.9.3. Competitive Scenario
8.3.9.4. Sweden Protein Purification And Isolation Market, 2021 - 2033 (USD Million)
8.3.10. Norway
8.3.10.1. Key Country Dynamics
8.3.10.2. Target Disease Prevalence
8.3.10.3. Competitive Scenario
8.3.10.4. Norway Protein Purification And Isolation Market, 2021 - 2033 (USD Million)
8.4. Asia Pacific
8.4.1. SWOT Analysis
8.4.2. Asia Pacific Protein Purification And Isolation Market, 2021 - 2033 (USD Million)
8.4.3. Japan
8.4.3.1. Key Country Dynamics
8.4.3.2. Target Disease Prevalence
8.4.3.3. Competitive Scenario
8.4.3.4. Japan Protein Purification And Isolation Market, 2021 - 2033 (USD Million)
8.4.4. China
8.4.4.1. Key Country Dynamics
8.4.4.2. Target Disease Prevalence
8.4.4.3. Competitive Scenario
8.4.4.4. China Protein Purification And Isolation Market, 2021 - 2033 (USD Million)
8.4.5. India
8.4.5.1. Key Country Dynamics
8.4.5.2. Target Disease Prevalence
8.4.5.3. Competitive Scenario
8.4.5.4. India Protein Purification And Isolation Market, 2021 - 2033 (USD Million)
8.4.6. Australia
8.4.6.1. Key Country Dynamics
8.4.6.2. Target Disease Prevalence
8.4.6.3. Competitive Scenario
8.4.6.4. Australia Protein Purification And Isolation Market, 2021 - 2033 (USD Million)
8.4.7. Thailand
8.4.7.1. Key Country Dynamics
8.4.7.2. Target Disease Prevalence
8.4.7.3. Competitive Scenario
8.4.7.4. Thailand Protein Purification And Isolation Market, 2021 - 2033 (USD Million)
8.4.8. South Korea
8.4.8.1. Key Country Dynamics
8.4.8.2. Target Disease Prevalence
8.4.8.3. Competitive Scenario
8.4.8.4. South Korea Protein Purification And Isolation Market, 2021 - 2033 (USD Million)
8.5. Latin America
8.5.1. SWOT Analysis
8.5.2. Latin America Protein Purification And Isolation Market, 2021 - 2033 (USD Million)
8.5.3. Brazil
8.5.3.1. Key Country Dynamics
8.5.3.2. Target Disease Prevalence
8.5.3.3. Competitive Scenario
8.5.3.4. Brazil Protein Purification And Isolation Market, 2021 - 2033 (USD Million)
8.5.4. Mexico
8.5.4.1. Key Country Dynamics
8.5.4.2. Target Disease Prevalence
8.5.4.3. Competitive Scenario
8.5.4.4. Mexico Protein Purification And Isolation Market, 2021 - 2033 (USD Million)
8.5.5. Argentina
8.5.5.1. Key Country Dynamics
8.5.5.2. Target Disease Prevalence
8.5.5.3. Competitive Scenario
8.5.5.4. Argentina Protein Purification And Isolation Market, 2021 - 2033 (USD Million)
8.5.6. Colombia
8.5.6.1. Key Country Dynamics
8.5.6.2. Target Disease Prevalence
8.5.6.3. Competitive Scenario
8.5.6.4. Colombia Protein Purification And Isolation Market, 2021 - 2033 (USD Million)
8.5.7. Peru
8.5.7.1. Key Country Dynamics
8.5.7.2. Target Disease Prevalence
8.5.7.3. Competitive Scenario
8.5.7.4. Peru Protein Purification And Isolation Market, 2021 - 2033 (USD Million)
8.5.8. Chile
8.5.8.1. Key Country Dynamics
8.5.8.2. Target Disease Prevalence
8.5.8.3. Competitive Scenario
8.5.8.4. Chile Protein Purification And Isolation Market, 2021 - 2033 (USD Million)
8.6. MEA
8.6.1. SWOT Analysis
8.6.2. MEA Protein Purification And Isolation Market, 2021 - 2033 (USD Million)
8.6.3. South Africa
8.6.3.1. Key Country Dynamics
8.6.3.2. Target Disease Prevalence
8.6.3.3. Competitive Scenario
8.6.3.4. South Africa Protein Purification And Isolation Market, 2021 - 2033 (USD Million)
8.6.4. Saudi Arabia
8.6.4.1. Key Country Dynamics
8.6.4.2. Target Disease Prevalence
8.6.4.3. Competitive Scenario
8.6.4.4. Saudi Arabia Protein Purification And Isolation Market, 2021 - 2033 (USD Million)
8.6.5. UAE
8.6.5.1. Key Country Dynamics
8.6.5.2. Target Disease Prevalence
8.6.5.3. Competitive Scenario
8.6.5.4. UAE Protein Purification And Isolation Market, 2021 - 2033 (USD Million)
8.6.6. Kuwait
8.6.6.1. Key Country Dynamics
8.6.6.2. Target Disease Prevalence
8.6.6.3. Competitive Scenario
8.6.6.4. Kuwait Protein Purification And Isolation Market, 2021 - 2033 (USD Million)
Chapter 9 Company Profiles
9.1. Company Categorization
9.2. Strategy Mapping
9.3. Company Market Share Analysis, 2024
9.4. Company Profiles/Listing
9.4.1 Thermo Fisher Scientific Inc.
9.4.1.1 Overview
9.4.1.2 Financial Performance (Net Revenue/Sales/EBITDA/Gross Profit)
9.4.1.3 Product Benchmarking
9.4.1.4 Strategic Initiatives
9.4.2 Merck KGaA
9.4.2.1 Overview
9.4.2.2 Sigma-Aldrich Corporation
9.4.2.2.1 Overview
9.4.2.3 Financial Performance (Net Revenue/Sales/EBITDA/Gross Profit)
9.4.2.4 Product Benchmarking
9.4.2.5 Strategic Initiatives
9.4.3 QIAGEN N.V.
9.4.3.1 Overview
9.4.3.2 Financial Performance (Net Revenue/Sales/EBITDA/Gross Profit)
9.4.3.3 Product Benchmarking
9.4.3.4 Strategic Initiatives
9.4.4 Bio-Rad Laboratories, Inc.
9.4.4.1 Overview
9.4.4.2 Financial Performance (Net Revenue/Sales/EBITDA/Gross Profit)
9.4.4.3 Product Benchmarking
9.4.4.4 Strategic Initiatives
9.4.5 Agilent Technologies
9.4.5.1 Overview
9.4.5.2 Financial Performance (Net Revenue/Sales/EBITDA/Gross Profit)
9.4.5.3 Product Benchmarking
9.4.5.4 Strategic Initiatives
9.4.6 Promega Corporation
9.4.6.1 Overview
9.4.6.2 Financial Performance (Net Revenue/Sales/EBITDA/Gross Profit)
9.4.6.3 Product Benchmarking
9.4.6.4 Strategic Initiatives
9.4.7 GE Healthcare
9.4.7.1 Overview
9.4.7.2 Financial Performance (Net Revenue/Sales/EBITDA/Gross Profit)
9.4.7.3 Product Benchmarking
9.4.7.4 Strategic Initiatives
9.4.8 Norgen Biotek Corp.
9.4.8.1 Overview
9.4.8.2 Product Benchmarking
9.4.8.3 Financial Performance (Net Revenue/Sales/EBITDA/Gross Profit)
9.4.8.4 Strategic Initiatives
9.4.9 Abcam plc
9.4.9.1 Overview
9.4.9.2 Financial Performance (Net Revenue/Sales/EBITDA/Gross Profit)
9.4.9.3 Product Benchmarking
9.4.9.4 Strategic Initiatives
9.4.10 Danaher
9.4.10.1 Overview
9.4.10.2 Financial Performance (Net Revenue/Sales/EBITDA/Gross Profit)
9.4.10.3 Product Benchmarking
9.4.10.4 Strategic Initiatives
Cross-segment Market Size and Analysis for Mentioned Segments
Additional Company Profiles
(Upto 5 With No Cost)
Additional Countries (Apart
From Mentioned Countries)
Country/Region-specific Report
Go To Market Strategy
Region Specific Market DynamicsRegion Level Market Share Import Export AnalysisProduction AnalysisOthers