Protein Crystallization Market Size, Share & Trends Analysis Report By Product (Instruments, Consumables, Software & Services), By Technology (X-ray Crystallography, Cryo-electron Microscopy), By End-user, By Region- Global Industry Analysis, Share, Growth, Regional Outlook and Forecasts, 2023-2032

The global protein crystallization market size was exhibited at USD 2.19 billion in 2022 and is projected to hit around USD 4.84 billion by 2032, growing at a CAGR of 8.26% during the forecast period 2023 to 2032.

Key Pointers:

• North America held the largest share of 35.75% in the global market in 2022.
• Asia Pacific region is estimated to expand at the fastest CAGR of 10.82% during 2023-2032.
• The consumables segment held the largest market share of 67.19% in 2022.
• The software & services segment is anticipated to expand at the fastest CAGR of 10.22% during the forecast years.
• The X-ray crystallography segment held the largest share of 53.42% in 2022.
• The cryo-electron microscopy segment is projected to expand at the highest CAGR of 11.95% during the forecast
• The pharmaceutical and biotechnology companies segment held the highest revenue share of 67.65% in 2022.
• The pharmaceutical and biotechnology companies segment is also anticipated to expand at the fastest pace with a CAGR of 8.34% during the forecast period. 

Protein Crystallization Market Report Scope

The rising demand for protein-based therapeutics, increasing funding & investments in proteomics research, and technological advancements in crystallography techniques are the key factors driving the market. Furthermore, major pharmaceutical applications associated with crystallization such as drug development, formulation, purification & separation, and drug delivery are anticipated to further boost the market during the study period.

Increasing funding & investments by several pharmaceutical and biotechnological companies are enhancing the R&D activities of proteomics in drug development. For instance, in January 2022, Protai raised funding of USD 8.0 million to develop a proteomics-based platform. This platform enables the viewing of new layers of disease on the protein level to reshape the drug discovery and development process. Hence, increasing funding may boost R&D activities, which ultimately increases the demand for protein crystallization techniques.

The sudden outbreak of COVID-19 led to an upsurge in research and development activities to design vaccines and drugs. Hence, it was important for researchers to study the structure, function, and pathogenesis of the virus. The crystallization techniques help researchers to determine the structure of SARS-CoV-2 proteins for the development of novel vaccines to treat the disease. For instance, researchers at Serum Institute of India Pvt. Ltd. developed a COVOVAX protein recombinant vaccine for COVID-19. Thus, the COVID-19 pandemic had a positive impact on the market.

Moreover, an increasing number of individuals have been utilizing protein-based drugs owing to their advantages such as low toxicity, high potency & specificity, and high tolerance by the human body. In addition, major players in the market are entering into partnerships and collaborations to develop protein-based therapeutics at more affordable costs for patients. For instance, in January 2022, Amgen entered into collaboration with Generate Biomedicines to discover and develop proteins for five targets across multiple modalities and therapeutic areas. Thus, such initiatives are expected to drive the adoption of protein crystallization methods during the estimated timeframe.

Furthermore, protein crystallization may aid in the identification of potential treatments for multiple diseases, from muscular dystrophy to cancer. For instance, according to an article published on NASA in July 2022, as said by researchers at the Japan Aerospace Exploration Agency, protein crystal growth in space may slow the progression of muscular dystrophy by half and potentially double the life span of many patients. Hence, the increasing R&D activities on protein crystals can significantly fuel the market during the estimated timeframe.

On the other hand, the high cost of instruments may restrain the market during the forecast years. On average a cryo-electron microscope costs about USD six million to seven million and an additional investment has to be spent on the infrastructure and supporting equipment. Such high costs may not be affordable for small- and medium-sized laboratories, which hampers market growth to a certain extent. In addition, challenges associated with the formulation and delivery of protein therapeutics may limit the market to some extent. However, operating players in the market are continuously working on the development of affordable instruments for crystallization.

Some of the prominent players in the Protein Crystallization Market include:

• Rigaku Corporation 
• FORMULATRIX
• METTLER TOLEDO
• Corning Incorporated
• Greiner Bio-One International GmbH
• HAMPTON RESEARCH CORP
• Jena Bioscience GmbH
• Bruker
• Creative Proteomics
• Molecular Dimensions

Segments Covered in the Report

This report forecasts revenue growth at global, regional, and country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2018 to 2032. For this study, Nova one advisor, Inc. has segmented the global Protein Crystallization market.

By Product 

• Instruments
  • Liquid Handling Instruments
  • Crystal Imaging Instruments
• Consumables
  • Reagents & Kits/Screens
  • Micro Plates
  • Others
• Software & Services

By Technology 

• X-ray Crystallography
• Cryo-electron Microscopy
• NMR Spectroscopy
• Others

By End-User

• Pharmaceutical And Biotechnology Companies
• Academic And Research Institutes

By Region

• North America
• Europe
• Asia-Pacific
• Latin America
• Middle East & Africa (MEA)