Bone Grafts and Substitutes Market (By Material Type: Allograft, Synthetic; By Application: Foot & Ankle, Craniomaxillofacial, Joint Reconstruction, Dental, Long Bone, Spinal Fusion; By End User: Hospital, Specialty Clinics, Others) - Global Industry Analysis, Share, Growth, Regional Outlook and Forecasts, 2022-2030

The global Bone Grafts and Substitutes market size was estimated at USD 3.7 billion in 2021 and is expected to surpass around USD 7.1 billion by 2030 and poised to grow at a compound annual growth rate (CAGR) of 7.51% during the forecast period 2022 to 2030.

Key Takeaways:

• By application, the U.S. bone grafts and substitutes market was valued at USD 981 million in 2021.
• North America dominated the market with over 41.0% share of the global revenue in 2021
• Asia Pacific is expected to grow at a CAGR of 7.8% in the forecast period.
• By material type, the allograft segment accounted for about 56% of the share in 2021.
• By application, the spinal fusion segment has had a dominant position with a share of about 61%.

The rising incidence of bone and joint disorders, increasing demand for dental bone grafts, growing requirement for dental bone grafts, and technological advancements are some key factors driving the market. The synthetic material type segment is anticipated to witness significant growth over the forecast period. This growth is due to the lesser risk of disease transmission, better acceptance among patients as compared to allografts, and products’ better biocompatibility.

The demand for orthopedic devices, which include bone grafts and substitutes, observed a radical decrease because of the rescheduling of elective surgeries during COVID-19. During the pandemic, various players in the market were negatively impacted and hence they adopted various strategies to deal with the pandemic. For instance, Bonesupport, a Swedish synthetic bone graft company, faced a slowdown in growth during the first half of the year as a direct impact of the COVID-19 pandemic. To combat the impact of COVID-19, the company adopted measures such as the work from home model for office-based employees, temporary work reduction for sales personnel, and short-time salary reductions. Hence, the COVID-19 pandemic resulted in declining market growth.

Growing cases of spinal deformities are driving this market. According to a CDC report, approximately 60% of the aged population and 32% of the adult population are suffering from spinal deformities, in the U.S., as of 2017. Around 488,000 spinal procedures were performed in the U.S. Moreover, the introduction of biocompatible synthetic grafts is expected to fuel market growth. The market in various countries is expected to witness diverse trends because of ethical issues in some of the Muslim and Jewish population-dominated countries. These countries include majorly the Middle Eastern countries, which are apprehensive about using xenografts for their orthopedic surgeries. Such factors hamper the market growth drastically.

Additionally, technological advancements and the growing geriatric population are boosting market growth. According to Population Reference Bureau’s 2018 statistics, from 13 countries to around 82 countries across the globe are expected to have more than 20% of the geriatric population (65 years and above) by 2050. Thus, perpetual growth in the population aged 60 years and above is anticipated to result in the increased prevalence of arthritis and joint disorders. Key players in the market are investing in the launch of new products and product approvals for sustaining in the market.

For instance, AlloSource stated that ProChondrix CR would have 2 years of shelf life based on the results of real-time testing, as of March 2019. ProChondrix CR helps in cartilage healing and is intended to match biochemical and biomechanical properties of normal hyaline cartilage, improve patient symptoms, and restore a smooth articular cartilage surface. The industry participants are focusing on product launches, partnerships, acquisitions, and strategic initiatives to sustain the competition. They are also involved in expanding the product penetration, regional presence, and revenue to maintain their position in the market.

Report Scope of the Bone Grafts and Substitutes Market

Material Type Insights

The allograft segment led the market and accounted for over 55.0% share of the global revenue in 2021. The allograft segment is further divided into the demineralized bone matrix and others. The adoption of allografts is increasing due to their properties, such as immediate structural support and osteoconductivity. Additionally, they do not require another surgery bone, which triggers fast wound healing and decreases the surgery time. These are commonly used in spine, hip, and knee areas. Demineralized bone matrices are easily available in various sizes and shapes, such as chips, pellets, and granules. In addition, they demonstrate both osteoinductive as well as osteoconductive properties, which increases their popularity, hence boosting the market growth.

The synthetic segment is anticipated to witness significant growth over the forecast period. This growth is due to the products’ better biocompatibility, lesser risk of disease transmission, and better acceptance among patients as compared to allografts. The synthetic segment is further classified into composites, ceramics, polymers, and BMP. The ceramics segment dominated the market in 2021 and is further sectioned into HAP, ß-TCP, α-TCP, bi-phasic calcium phosphates (BCP), and others. Ceramic material gets easily reabsorbed in a patient’s body, which maintains the position of their bone and has a reduced risk of infection or disease transmission. Furthermore, the segment is securing popularity owing to its smaller time period of surgery, controlled blood loss, and reduced pain involved in the procedure performed.

Application Insights

The spinal fusion segment held the largest revenue share of over 60.0% in 2021. Based on application, the market is classified into long bone, spinal fusion, foot and ankle, joint reconstruction, craniomaxillofacial, and dental. The growth can be attributed to the rising adoption of bone graft materials for spondylosyndesis. Moreover, the rising geriatric population prone to orthopedic ailments is pushing the need for corrective surgical treatment, thereby anticipated to boost the market growth in the near future. According to the World Health Organization, the geriatric population is expected to double from 12% to 22% from 2015 to 2050.

Increasing usage of grafts for dental procedures is estimated to provide lucrative opportunities for the segment to grow through the forecast period. The grafts are usually used as a scaffold and filler in order to facilitate bone formation and promote healing. Growing acceptance of dental implant surgical procedures along with advanced techniques such as bone regeneration and bone grafts is anticipated to boost the market growth. In addition to this, increasing success rates of dental implants are resulting in the growing demand for bone grafts and substitutes in the market. As per Trend Statistics, the number of dental implant procedures in 2019 has increased by 6.3% since the previous year.

 The joint reconstruction segment is expected to witness steady growth over the forecast period owing to the increasing number of knee replacement and hip replacement procedures. According to the center for orthopedic and neurological care and research, the number of total knee replacement surgeries is estimated to increase by 673% to 3.5 million procedures annually, by 2030. The long bone segment is anticipated to witness significant growth in the years to come. Injuries and trauma to extremities due to road accidents and sports injuries are among the factors boosting the adoption of bone grafts and substitutes in long bone surgeries. Major players operating in this segment include Baxter, Stryker, and Medtronic, among others.

Regional Insights

North America dominated the market with over 41.0% share of the global revenue in 2021. Growing awareness related to the commercially accessible innovative products, accessibility of a well-developed healthcare structure, and higher healthcare expenditure of 16.9% in 2018 is the major aspects contributing to the regional market growth. The market in the U.S. is leading the North American as well as global market by generating the maximum demand for bone grafts and substitutes because of the growing number of trauma-related injuries as well as cases of orthopedic disease.

Asia Pacific is estimated to witness lucrative growth during the forecast period. This growth can be attributed to rising medical tourism and favorable government initiatives. On the other hand, stringent regulatory guidelines restrict the adoption in a few nations. For instance, in South Korea, the product has to be approved before marketing by the Korean Food and Drug Administration (KFDA). In Australia, the products are regulated by the Therapeutic Goods Administration (TGA). The stringent regulatory outlook in Japan restricts the entry of foreign players into the country. Though, with the latest approval of DBM in Japan in 2019, the allograft market is set to record lucrative growth in the Asia Pacific over the next decade.

Some of the prominent players in the Bone Grafts and Substitutes Market include:

• Smith & Nephew plc (U.K.)
• SeaSpine (U.S.)
• AlloSource (U.S.)
• Bioventus (U.S.) 
• Medtronic PLC (Ireland)
• DePuy Synthes Companies (Johnson & Johnson Services, Inc.) (U.S.)
• Stryker (U.S.)
• Zimmer Biomet (U.S.)
• MTF Biologics (U.S.)
• Orthofix Holdings, Inc. (U.S.)

Segments Covered in the Report

This report forecasts revenue growth at global, regional, and country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2017 to 2030. For this study, Nova one advisor, Inc. has segmented the global Bone Grafts and Substitutes market

By Material Type

• Allograft
• Demineralized Bone Matrix
• Others
• Synthetic
• Ceramics
• HAP
• β-TCP
• α-TCP
• Bi-phasic Calcium Phosphates (BCP)
• Others
• Composites
• Polymers
• Bone Morphogenic Proteins (BMP)

By Application

• Foot & Ankle
• Craniomaxillofacial
• Joint Reconstruction
• Dental
• Long Bone
• Spinal Fusion

By End User

• Hospital
• Specialty Clinics
• Others

By Geography

North America

• U.S.
• Canada

Europe

• Germany
• France
• United Kingdom
• Rest of Europe

Asia Pacific

• China
• Japan
• India
• Southeast Asia
• Rest of Asia Pacific

Latin America

• Brazil
• Rest of Latin America

Middle East & Africa (MEA)

• GCC
• North Africa
• South Africa
• Rest of Middle East & Africa

Key Benefits for Stakeholders

• This report provides a quantitative analysis of the market segments, current trends, estimations, and dynamics of the global Bone Grafts and Substitutes industry analysis from 2022 to 2030 to identify the prevailing Bone Grafts and Substitutes industry opportunity.
• The market research is offered along with information related to key drivers, restraints, and opportunities.
• Porter's five forces analysis highlights the potency of buyers and suppliers to enable stakeholders make profit-oriented business decisions and strengthen their supplier-buyer network.
• In-depth analysis of the global Bone Grafts and Substitutes industry segmentation assists to determine the prevailing market opportunities.
• Major countries in each region are mapped according to their revenue contribution to the global market.
• Market player positioning facilitates benchmarking and provides a clear understanding of the present position of the market players.
• The report includes the analysis of the regional as well as global Bone Grafts and Substitutes industry trends, key players, market segments, application areas, and market growth strategies.