Huntington's Disease Treatment Market Size, Share & Trends Analysis Report By Treatment (Symptomatic Treatment, Disease-Modifying Therapies), By Region (North America, Europe, APAC, Latin America, MEA)- Global Industry Analysis, Share, Growth, Regional Outlook and Forecasts, 2022-2030

The global Huntington’s Disease Treatment market size was estimated at USD 362.7 million in 2021 and is expected to surpass around USD 1.20 billion by 2030 and poised to grow at a compound annual growth rate (CAGR) of 19.8% during the forecast period 2022 to 2030.

Key Takeaways:

• By treatment, the U.S. Huntington’s Disease Treatment market was valued at USD 251.9 million in 2021 and expected to witness growth at a CAGR of 18.8% from 2022 to 2030.
• The symptomatic treatment segment accounted for the largest revenue share in 2021 owing to the product availability and patent protection. Disease-modifying therapies is anticipated to be the fastest-growing segment over the forecast years due to the entry of SAGE-718, and Cellavita-HD
• Companies are now focusing on the development of treatments that can be injected directly into the brain to directly inhibit the formation of mutant HTT protein, instead of targeting the mutant protein
• Drugs with novel targets in early-phase development include Cellavita and Azidus Brazil’s Cellavita HD (stem cell therapy), Sangamo Therapeutics, Inc. mHTT ZFP (zinc finger protein), and UniQure’s AMT-130 (gene therapy)
• North America held the highest revenue share in 2021 and is expected to dominate the market over the forecast period due to better reimbursement facilities and the high burden of HD in the U.S. and Canada

The expected label expansion of Ingrezza for treating chorea associated with Huntington’s disease, high burden of HD in western countries, and strong product pipeline of disease-modifying therapies are anticipated to be major drivers for the market.HD roughly affects 30,000 people in North America, with a prevalence of 5.7 per 100,000 people. HD in children is considerably rarer, accounting for about 5% to 10% of all cases. It affects up to 10 out of 100,000 people in Europe.

Huntington's Disease (HD) is a progressive neurological condition caused by CAG expansions in the Huntingtin (Htt) gene. It affects one out of every 10,000 people in the United States. Healthy people have less than 35 CAG repetitions, whereas HD patients have CAG expansions ranging from 36 to 200. The prevalence varies by more than ten-fold between geographical locations, which can be related to variations in case ascertainment and diagnostic criteria. The Asian population has consistently had a lower prevalence, while Europe, North America, and Australia have a higher prevalence. Several small molecules in clinical development are focused on using immunomodulatory drugs to target the overactive immune system in HD.

 Annexon, Inc. is engaged in the development of ANX005-an experimental monoclonal antibody that targets abnormal C1q activity in complement-mediated neurodegenerative diseases, such as HD. This innovative medication is administered intravenously (IV) and is meant to suppress C1q and the complete classical complement system. In November 2020, the company initiated a phase 2 clinical trial of ANX005 for treating HD patients. Stem cell therapy is also generating interest as a potential treatment for HD. Currently, Cellavita, in collaboration with AzidusPharma, is investigating stem cell therapy, CELLAVITA-HD in phase 2/ 3 ADORE-DH trial.

Report Scope of the Huntington’s Disease Treatment Market

However, drug development for HD has faced significant obstacles as several therapies have failed to demonstrate efficacy or were associated with significant toxicity. In March 2021, F. Hoffmann-La Roche Ltd. discontinued the dosing in the phase III GENERATION HD1 study of tominersen in manifest HD. The conclusion was made on the basis of findings of an unblinded Independent Data Monitoring Committee's (iDMC) preplanned examination of data from the phase III research. During analysis of this data, no new or developing safety signals for tominersen were discovered.COVID-19 pandemic has had a slight negative impact on the market for Huntington’s disease treatment. However, the delays in conducting clinical trials due to the pandemic can delay the entry of pipeline candidates into the market.

Treatment Insights

The symptomatic treatment segment held the largest revenue share of 100.0% in 2021 and is expected to dominate the market for Huntington’s disease treatment over the forecast period. This growth is due to the availability of symptom management products and patent protection for these products. Xenazine and Austedo are considered first-line therapy for chorea associated with Huntington’s disease. The R&D of potential product candidates for symptom management of Huntington’s disease may contribute to segment growth. In October 2021, the U.S. FDA granted orphan drug designation to SOM BIOTECH’s drug SOM3355 for the treatment of chorea associated with Huntington’s disease. As a result, the product will have exclusivity for 7 years upon U.S. FDA approval.

The disease-modifying therapies segment is anticipated to witness the fastest growth over the forecast period. This is owing to an increase in R&D for disease-modifying therapy coupled with a rise in the demand for advanced products, such as gene therapy and stem cell therapy. The favorable government initiatives such as Fast Track Designation by the U.S. FDA for accelerating the registration process may fuel the market in the coming years. For instance, in September 2021, U.S. FDA granted fast track designation to Sage Therapeutics’s drug, SAGE-718, as a potential treatment for Huntington’s Disease.

Regional Insights

North America held the largest revenue share of 76.2% in the Huntington’s disease treatment market in 2021. This growth is due to the high burden of the disease, increased healthcare expenditure, technological advancements, proactive government initiatives, and increased patient awareness about treatment products for Huntington’s disease. Major players such as H. Lundbeck A/S and Teva Pharmaceutical Industries Ltd. support market growth by introducing symptom management products.

In Asia Pacific, the market for Huntington’s disease treatment is expected to witness significant CAGR over the forecast period due to increased product penetration, untapped potential, and the growing prevalence of the disease in developing countries over the forecast period. A rising number of initiatives being undertaken by governments to improve the health status of the population is expected to drive the growth of the market in the region. However, the market for Huntington’s disease treatment is competitive, which may hamper its growth in this region. For instance, in July 2021, Teva Pharmaceutical Industries Ltd. filed a patent lawsuit against Indian generic manufacturers Lupin Ltd. and AurobindoPharma Ltd-to prevent them from releasing a generic version of Austedo in the market.

Key Companies & Market Share Insights

Key players are contributing to market growth by adopting various strategies, such as new product development and partnerships to gain a higher market share.

• In September 2021, NeuExcell Therapeutics Inc entered into a partnership with Spark Therapeutics, Inc. (F. Hoffmann La Roche Ltd. owned subsidiary) for the development of gene therapy for treating HD patients. Under the terms of the agreement, NeuExcell Therapeutics is entitled to receive upfront license fees, R&D, and sales milestone payments of up to approximately USD 190 million and additional product royalties.
• In May 2020, Teva Pharmaceutical Industries Ltd. received NMPA approval for Austedo in China for the treatment of chorea associated with HD. China is the second country after the U.S. to approve AUSTEDO. This geographic expansion of the company is expected to provide a larger patient base and revenue growth.
• In September 2021, Prilenia Therapeutics B.V. announced its participation in H.C. Wainwright 23rd Annual Global Investment Conference, Cantor Virtual Global Healthcare Conference, and European Huntington's Disease Network for showcasing the topline results of phase 3 candidatepridopidine. These healthcare conferences are an excellent platform for increasing the customer base.

Some of the prominent players in the Huntington’s disease treatment market include:

• H. Lundbeck A/S
• Teva Pharmaceutical Industries Ltd.
• Bausch Health Companies Inc.
• Hetero
• Lupin
• Hikma Pharmaceuticals PLC
• Dr. Reddy’s Laboratories Ltd.
• Sun Pharmaceutical Industries Ltd.

Segments Covered in the Report

This report forecasts revenue growth at global, regional, and country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2017 to 2030. For this study, Nova one advisor, Inc. has segmented the global Huntington’s Disease Treatment market

• Treatment
• Symptomatic treatment
• Disease-modifying therapies

By Geography

North America

• U.S.
• Canada

Europe

• Germany
• France
• United Kingdom
• Rest of Europe

Asia Pacific

• China
• Japan
• India
• Southeast Asia
• Rest of Asia Pacific

Latin America

• Brazil
• Rest of Latin America

Middle East & Africa (MEA)

• GCC
• North Africa
• South Africa
• Rest of Middle East & Africa

Key Points Covered in Huntington’s Disease Treatment Market Study:

• Growth of Huntington’s Disease Treatment in 2022
• Market Estimates and Forecasts (2017-2030)
•  Brand Share and Market Share Analysis
•  Key Drivers and Restraints Shaping Market Growth
•  Segment-wise, Country-wise, and Region-wise Analysis
•  Competition Mapping and Benchmarking
•  Recommendation on Key Winning Strategies
•  COVID-19 Impact on Demand for Huntington’s Disease Treatment and How to Navigate
•  Key Product Innovations and Regulatory Climate
•  Huntington’s Disease Treatment Consumption Analysis
•  Huntington’s Disease Treatment Production Analysis
•  Huntington’s Disease Treatment and Management