Organ Preservation Market (By Solution; By Organ Type; By Preservation Technique; By Region) - Industry Analysis, Share, Growth, Regional Outlook and Forecasts, 2026-2035

Organ Preservation Market Size and Growth 2026 to 2035

The organ preservation market size was exhibited at USD 246.82 million in 2025 and is projected to hit around USD 477.76 million by 2035, growing at a CAGR of 6.83% during the forecast period 2026 to 2035.

Organ Preservation Market Key Takeaways:

• Perfadex segment is anticipated to witness the fastest CAGR over the forecast period.
• The kidney segment held the largest market share in 2025.
• The heart segment is anticipated to witness the fastest CAGR over the forecast period.
• The static cold storage segment held the largest share in 2025 owing to its wide applicability and increase in use.
• The normothermic machine perfusion segment is anticipated to witness the fastest CAGR over the forecast period.
• North America held the largest market share in 2024 and is expected to maintain its dominance over the forecast period.
• Asia Pacific is anticipated to witness the fastest growth over the forecast period.

Organ Preservation Market Outlook

• Market Growth Overview: The organ preservation market is expected to grow significantly between 2025 and 2034, driven by the improved healthcare infrastructure, increased donor availability, and surging demand for transplants. 
• Sustainability Trends: Sustainability trends involve reusable and eco-friendly systems, advanced preservation techniques, and shift towards from machine perfusion technology. 
• Major Investors: Major investors in the market include TransMedics, XVIVO Perfusion, Dr. Franz Kohler Chemie GmbH, BioLife Solutions, and Paragonix Technologies.

Organ Preservation Market Overview

The organ preservation market is a critical segment within the organ transplantation ecosystem, ensuring that organs remain viable between procurement and transplantation. Successful transplantation outcomes depend heavily on the quality and viability of preserved organs, making effective preservation methods and solutions indispensable.

Organ preservation involves a combination of specialized solutions, temperature regulation techniques, and mechanical devices designed to maintain organ integrity and function during transport and prior to implantation. The global increase in organ transplant procedures, driven by the rising burden of chronic organ diseases like end-stage renal disease, liver cirrhosis, and heart failure, is significantly driving the demand for advanced preservation technologies.

In addition to growing transplant volumes, technological innovation in preservation techniques including hypothermic machine perfusion (HMP) and normothermic machine perfusion (NMP) is reshaping traditional methods like static cold storage (SCS), offering enhanced graft viability and extended preservation times.

Furthermore, government initiatives promoting organ donation awareness, expanded donor pools including marginal donors, and efforts to reduce organ wastage are contributing to the growing demand for high-quality preservation solutions worldwide. As a result, the organ preservation market is poised for substantial expansion in the coming years.

How AI is Impacting on Organ Preservation Market

Artificial intetelligence is transforming the organ preservation industry by shifting from traditional static cold storage to advanced, data-driven machine perfusion techniques. AI algorithm are used to monitor perfusion parameters in real-time, such as flow rates, pressure, and lactate level, to assess graft viability and reduce organ waste. AI enhances logistical efficiency by optimizing transport routes, which reduces cold ischemia time and improves post-transplant patient outcomes. This technology is also enabling personalized organ preservation solutions tailored to specific organs and patient needs, enhancing overall graft survival.   

Supply Chain Analysis of the Organ Preservation Market

• R&D and Product Development: This upstream stage involves the development of specialized preservation solutions and innovative machine perfusion devices, focusing on enhancing organ viability and minimizing ischemia-reperfusion injury. 
  Key Players: XVIVO Perfusion AB, TransMedics, and OrganOx Limited.
• Raw Material Sourcing and Chemical Manufacturing: This stage includes the manufacturing of essential chemical agents, such as electrolytes, colloid osmotic agents (dextran), and specific nutrients required for formulating organ-protective solutions.
  Key Players: Dr. Franz Köhler Chemie GmbH, Essential Pharmaceuticals, and Preservation Solutions, Inc.
• Logistics, Distribution, and Transport: This involves the cold-chain transport of the organ in a controlled environment from the donor location to the transplant center, ensuring the preservation solution remains effective. 
  Key Players: Paragonix Technologies and TransMedics.

Major Trends in the Organ Preservation Market

• Shift Toward Machine Perfusion Technologies: Increasing adoption of hypothermic and normothermic machine perfusion over traditional static cold storage.

• Rising Use of Marginal and Expanded Criteria Donors: Driving demand for enhanced preservation techniques to optimize suboptimal donor organs.

• Development of Specialized Preservation Solutions: Customized fluids targeting specific organ requirements (e.g., Custodiol HTK, Perfadex).

• Integration of Real-time Organ Monitoring: Advances in perfusion machines allowing real-time assessment of organ viability pre-transplantation.

• Focus on Prolonged Preservation Times: Research into extending organ viability beyond traditional 24-hour windows to address logistical challenges.

• Public-Private Partnerships Promoting Organ Donation Programs: Especially in emerging economies, expanding the donor base.

• Increased R&D in Normothermic Perfusion: Moving closer to clinical mainstream adoption across multiple organ types.

• Expansion into Asia-Pacific Markets: Rising healthcare investments and growing transplant infrastructure in emerging countries.

Report Scope of Organ Preservation Market

Organ Preservation Market Dynamics 

Driver

Rising Global Burden of Chronic Diseases Leading to Increased Organ Transplants

The most prominent driver for the organ preservation market is the rising global burden of chronic diseases leading to increased organ transplantation procedures.

Diseases such as chronic kidney disease (CKD), liver cirrhosis, congestive heart failure, and chronic obstructive pulmonary disease (COPD) are escalating globally due to aging populations, lifestyle-related risk factors, and increasing incidences of diabetes and hypertension. As end-stage organ failure becomes more prevalent, the demand for organ transplants rises dramatically.

Successful organ transplantation depends not only on surgical expertise but also on the ability to preserve organs effectively from the point of donation to implantation. Therefore, the growing number of transplantations particularly kidney, liver, heart, and lung directly correlates with heightened demand for advanced preservation techniques and solutions.

Restraint

High Cost and Limited Availability of Advanced Preservation Technologies

A significant restraint facing the market is the high cost and limited availability of advanced preservation technologies, particularly in low- and middle-income countries.

Advanced preservation techniques such as hypothermic and normothermic machine perfusion require expensive equipment, specialized preservation solutions, and highly trained personnel. These systems represent a substantial investment for healthcare facilities already burdened with high transplantation costs.

Additionally, the uneven distribution of transplant infrastructure means that many healthcare centers in emerging regions still rely heavily on traditional static cold storage methods, limiting the adoption of superior yet costlier machine-based techniques. Bridging affordability gaps through innovation and policy support will be critical to overcoming this restraint.

Opportunity

Expansion of Normothermic Machine Perfusion (NMP) Applications

An emerging and transformative opportunity lies in the expansion of normothermic machine perfusion (NMP) applications across multiple organ types.

Normothermic perfusion technology maintains donor organs at physiological temperatures with oxygenated blood or perfusate, enabling metabolic activity to continue during preservation. This technique allows for better assessment of organ function, repair interventions before transplantation, and extended preservation windows compared to cold storage.

Initially developed for liver and heart preservation, NMP is now being investigated and clinically adopted for kidneys and lungs, broadening its market potential. Companies investing in NMP platforms and research collaborations stand to capture a significant share of the growing preference for dynamic, superior organ preservation methods.

Organ Preservation Market Segmental Insights

By Solution Insights

University of Wisconsin (UW) solution dominates the solution segment, widely recognized as the gold standard for preserving kidneys, livers, and pancreases. It is the most extensively studied and utilized static cold storage solution, offering effective protection against ischemia-reperfusion injury during transplantation.

Perfadex is growing fastest, particularly in the preservation of lungs. Perfadex’s unique low-potassium, dextran-based composition offers superior endothelial protection and anti-edema properties, enabling longer lung preservation times. With lung transplantation becoming more prevalent globally, especially for conditions like cystic fibrosis and pulmonary fibrosis, Perfadex's adoption rate continues to climb rapidly.

By Organ Type Insights

Kidney preservation dominates the organ type segment, reflecting the high volume of kidney transplants performed globally. Kidney transplants account for over 60% of all solid organ transplants, primarily due to the widespread burden of end-stage renal disease (ESRD) and the established success rates of renal transplantation.

Heart preservation is growing fastest, driven by improved heart transplant outcomes, expanding donor pools through better organ preservation, and the emergence of ex vivo perfusion systems that allow functional evaluation of donor hearts. Technological advancements enabling extended heart preservation times are transforming traditionally time-sensitive heart transplantation logistics.

By Preservation Technique Insights

Static cold storage (SCS) dominates the preservation technique segment, remaining the most commonly used method globally due to its simplicity, low cost, and adequate efficacy for many organ types under standard conditions.

Normothermic machine perfusion (NMP) is growing fastest, offering superior graft preservation, real-time functional assessment, and the possibility of organ repair prior to transplantation. As clinical evidence supporting NMP’s benefits accumulates, its adoption is expanding beyond experimental and trial settings into routine clinical practice.

Organ Preservation Market By Regional Insights

North America holds the largest share of the global organ preservation market, driven by high transplant volumes, advanced healthcare infrastructure, and strong adoption of innovative preservation technologies.

The United States accounts for the majority of regional revenue, supported by extensive organ donation networks like UNOS (United Network for Organ Sharing), robust funding for transplantation research, and widespread clinical usage of hypothermic and normothermic perfusion technologies.

Additionally, favorable reimbursement policies and the presence of leading organ preservation solution and device manufacturers strengthen North America’s leadership position.

Asia-Pacific is the fastest-growing region, fueled by rising prevalence of chronic diseases, expanding transplant infrastructure, and improving healthcare access in countries like China, India, Japan, and Australia.

Government initiatives to promote organ donation, increasing healthcare investments, and growing awareness about advanced transplant practices are accelerating regional market growth. The expansion of living donor transplantation programs and the adoption of machine perfusion techniques in select Asian transplant centers further drive market momentum.

U.S. Organ Preservation Market Trends 

U.S.’s integrating advanced preservation solutions like UW and Custodiol HTK with oxygen-carrying additives, providers are successfully mitigating ischemia-reperfusion injuries and enhancing graft survival rates. The adoption of these physiological maintenance technologies positions the organ preservation sector as a critical enabler of expanded transplant volumes and improved long-term patient outcomes. 

China Organ Preservation Market Trends 

China’s high clinical volume of end-stage renal disease, which has positioned kidney preservation as primary revenue anchor. By integrating advanced solutions from global leaders, such as TransMedics and XVIVO alongside emerging domestic providers, the sector is enhancing organ viability for an aging population with a high chronic disease burden. The move towards normothermic and hypothermic physiological maintance ensures China remains the primary growth in the region transplant infrastructure. 

Key Players in the Organ Preservation Market

• XVIVO Perfusion: XVIVO specializes in machine perfusion technologies (Kidney Assist, Liver Assist, XPS) that keep organs alive and functioning outside the body, as well as the industry-standard STEEN Solution for lung assessment. 
• TransMedics: As the developer of the Organ Care System (OCS), TransMedics pioneered portable, normothermic machine perfusion that keeps hearts, livers, and lungs in a "beating" or functioning, warm state during transport. 
• 21st Century Medicine: This company focuses on advanced cryobiological research, specifically developing specialized perfusates and protocols for the long-term, ultra-low temperature, vitrification-based storage of human organs. 
• CryoLife, Inc. (now Artivion): CryoLife pioneered the use of proprietary cryopreservation and decellularization technology (SynerGraft) to process and preserve human cardiac and vascular tissues for transplant. 
• Bridge to Life Ltd.: Bridge to Life is a key provider of organ preservation solutions, specializing in cold storage solutions designed to maintain organ viability during transportation. 

Recent Developments

• March 2025: TransMedics Group announced FDA approval of its Organ Care System (OCS) Heart for broader use in DCD (donation after circulatory death) heart transplantation procedures.

• February 2025: XVIVO Perfusion AB launched its XPS™ Lung Preservation System with upgraded real-time lung evaluation capabilities across Europe.

• January 2025: Bridge to Life Ltd. announced the acquisition of assets from a U.S.-based NMP startup, strengthening its position in dynamic organ preservation technologies.

• December 2024: Paragonix Technologies secured expanded FDA clearance for its SherpaPak™ Cardiac Transport System, offering enhanced cardiac graft preservation during long-distance transports.

• November 2024: OrganOx Ltd. reported successful clinical trial results for its metra® liver perfusion device, supporting extended normothermic preservation up to 24 hours.

Segments Covered in the Report

This report forecasts revenue growth at country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2025 to 2035. For this study, Nova one advisor, Inc. has segmented the organ preservation market

By Solution

• University of Wisconsin (UW)
• Custodial HTK
• Perfadex
• Others

By Organ Type

• Kidneys
• Liver
• Lung
• Heart
• Others

By Preservation Technique

• Static Cold Storage
• Hypothermic Machine Perfusion
• Normothermic Machine Perfusion
• Others

By Regional

• North America
• Europe
• Asia Pacific
• Latin America
• Middle East and Africa (MEA)