Separation Systems For Commercial Biotechnology Market Size | Companies
The global separation systems for commercial biotechnology market size was valued at USD 25.85 billion in 2023 and is anticipated to reach around USD 46.78 billion by 2033, growing at a CAGR of 6.11% from 2024 to 2033.
Separation systems are crucial for purifying valuable biomolecules from complex mixtures in biopharma production. The rise of biopharmaceuticals and personalized medicine fuels this growing demand for highly pure biologics.
In addition, advancements in automation and technology are making these systems more efficient and driving their use in various biotech applications. Increased R&D investments and a growing biotechnology industry in emerging regions are expected to further propel the market growth.
The increasing regulatory requirements for purity and safety in biotechnological products is a significant driver. Regulatory bodies such as the Food and Drug Administration and the European Medicines Agency impose stringent guidelines on the purity of biologics, necessitating advanced separation technologies to ensure compliance. These systems are very important in eliminating impurities and contaminants and improving the quality and safety of the products. Therefore, it is observed that due to increasing governmental standards, especially in drug safety and purity, biopharmaceutical companies are focusing on innovative separation technologies, thereby driving the market.
According to the U.S. FDA, biologics manufacturers must adhere to several regulatory sections including 21 CFR Part 600 (General Biological Products Standards), 21 CFR Part 601 (Licensing), 21 CFR Part 610 (General Biological Products Standards), 21 CFR Part 211 (Current Good Manufacturing Practice for Finished Pharmaceuticals), and 21 CFR Part 1271 (Human Cells, Tissues, and Cellular and Tissue-Based Products), covering manufacturing, quality control, labeling, and post-market surveillance to ensure the safety, purity, and potency of biologic products.
The increasing focus on sustainability and environmental concerns within the biotechnology sector is anticipated to drive market growth. As industries strive to reduce their environmental footprint, there is a growing demand for energy-efficient separation systems that produce minimal waste and utilize eco-friendly materials. Manufacturers are responding by developing technologies that enhance separation efficiency and align with sustainability goals, thereby attracting environmentally conscious biotech companies. For instance, in 2023, Merck & Co., Inc.'s life science portfolio expanded to include 2,500 Greener Alternative Products, a 34% increase from the previous year. In addition, they actively collaborated with industry peers through the Sustainable Markets Initiative Health Systems Taskforce to drive sustainable changes across industries.
| Report Attribute | Details |
| Market Size in 2024 | USD 27.43 Billion |
| Market Size by 2033 | USD 46.78 Billion |
| Growth Rate From 2024 to 2033 | CAGR of 6.11% |
| Base Year | 2023 |
| Forecast Period | 2024 to 2033 |
| Segments Covered | Method, application, region |
| Market Analysis (Terms Used) | Value (US$ Million/Billion) or (Volume/Units) |
| Report Coverage | Revenue forecast, company ranking, competitive landscape, growth factors, and trends |
| Key Companies Profiled | Thermo Fisher Scientific Inc.; QIAGEN; Horizon Discovery Ltd.; OriGene Technologies, Inc.; Oxford Biomedica PLC; SignaGen Laboratories; Flash Therapeutics; Takara Bio Inc.; Bio-Rad Laboratories, Inc.; System Biosciences, LLC.; Promega Corporation; F. Hoffmann-La Roche Ltd; Revvity; Catalent, Inc. |
Method Insights
Conventional methods dominated the market and accounted for a share of 69.29% in 2023 driven by their established reliability and cost-effectiveness. These methods, including centrifugation and filtration, have a long history of proven efficacy and regulatory acceptance, encouraging continued use. In addition, technological advancements have enhanced the efficiency and scalability of conventional systems, making them preferable for large-scale biotechnological applications.
Modern methods are expected to grow at the fastest CAGR of 7.0% over the forecast period because they provide higher precision and efficiency in separating complex biomolecules. Innovations in chromatography and membrane technologies enhance the purification process, increasing demand for high-purity biopharmaceuticals. Moreover, the rising investment in research and development for novel biotechnological applications supports the adoption of these advanced separation techniques. For instance, in February 2024, Thermo Fisher Scientific Inc. launched an ion chromatography system called Dionex Inuvion Ion Chromatography (IC). It's designed to be flexible and handle various analyses, making it a single solution for labs to study ions and small polar molecules. This simplifies ion analysis for researchers of all levels.
Application Insights
The pharmaceutical segment dominated and accounted for the share of 39.19% of the market in 2023 due to growing industry focus and spending on the manufacturing of timely drugs. The rise of biopharmaceuticals, personalized medicine, and stricter drug purity standards fuel the demand for advanced separation techniques in the biopharma market.
The food and cosmetics segment are projected to grow at a CAGR of 7.0% over the forecast period due to increased customer awareness about natural and clean-label products. Better extraction and purification tech means safer, higher-quality food and cosmetics. Consumers wanting healthy, organic products and stricter regulations are pushing manufacturers to adopt these advanced separation methods. For instance, in October 2023, Organic Harvest entered the color cosmetics category by launching a new makeup line with toxin-free and cruelty-free formulations. The company introduced products that prioritize both skin health and environmental well-being. This initiative aligns with the increasing demand for eco-friendly and safe beauty options.
Regional Insights
North America separation systems for commercial biotechnology dominated the market in 2023 due to its well-established pharmaceutical and biotechnology industries, which drive high demand for advanced separation technologies. Significant investments in research and development, coupled with a robust regulatory framework, also contributed to this dominance. The region's strong focus on innovation and technological advancements further propelled growth in separation systems. Furthermore, the existence of major biopharmaceutical companies and some leading research institutions in North America supported the expansion of the market.
U.S. Separation Systems for Commercial Biotechnology Market Trends
The U.S. separation systems for commercial biotechnology market dominated North America with a share of 78.19% in 2023 due to substantial federal funding, initiatives taken by authorities, and private investments in biotech research and development. The country’s advanced healthcare infrastructure and presence of leading biotechnology companies also fueled market growth. Furthermore, a high demand for innovative biopharmaceuticals and personalized medicine drove the adoption of cutting-edge separation technologies. For instance, established under the Agriculture, Food, Conservation, and Trade Act of 1990, the U.S. Department of Agriculture (USDA) Biotechnology Risk Assessment Grants (BRAG) program supports research on the environmental impact of genetically engineered organisms (GE). This program assesses risks associated with introducing GE organisms into the environment, aiming to generate new information to make science-based decisions with the help of regulatory agencies.
Europe Separation Systems for Commercial Biotechnology Market Trends
Europe separation systems for the commercial biotechnology market grew high in 2023. This is due to robust investments in regional biopharmaceutical research and development. In addition, stringent regulatory standards for drug purity and quality are enhancing the adoption of advanced separation technologies. Furthermore, the increasing focus on personalized medicine and biotechnological innovations further propelled market growth in Europe. According to the Wallonia Export and Investment Agency, Belgium leads Europe in biopharmaceutical R&D investment, spending nearly 70% more than Denmark and Slovenia. In 2021, 578 clinical trials, a 20% increase from the previous year, were approved in Belgium, which ranked second in clinical trials per capita. In addition, Belgium ranks second for biopharmaceutical patent applications per capita, filing over one application daily and third for the share of biopharmaceutical patents in total applications.
The UK separation systems for the commercial biotechnology market are expected to grow higher in the coming years due to increased government support and funding for biotechnology research and development initiatives. The presence of world-class research institutions and strong collaborations between educational institutions and industry are also driving advancements in separation technologies. Furthermore, the rising demand for biopharmaceuticals and the focus on sustainable production processes are anticipated to propel market growth further.
Asia Pacific Separation Systems for Commercial Biotechnology Market Trends
Asia Pacific separation systems for the commercial biotechnology market are anticipated to grow significantly due to expanding biopharmaceutical manufacturing capabilities in countries such as China and India. In addition, healthcare expenditures are increasing, along with significant rises in investments in biotechnology infrastructure, which is driving the growth in this region. Furthermore, a growing focus on developing innovative biotechnological solutions and the presence of a large patient population are driving the adoption of advanced separation technologies in the region.
China separation systems for the commercial biotechnology market held a substantial share in 2023 due to its rapid expansion in biopharmaceutical manufacturing capabilities and biotechnology infrastructure. Government initiatives promoting innovation and biotech investment, alongside favorable regulatory policies, have stimulated market growth. In addition, collaborations between domestic and international biotech firms have increased the adoption of advanced separation technologies in China. For instance, from 2010 to 2020, China's biopharma sector surged, with market capitalization leaping from USD 1 billion to over USD 200 billion and startup funding doubling to USD 26.12 billion. During this period, 141 new biopharma companies emerged, outpacing the 79 formed in the previous decade. This contrasts sharply with declines in biotech companies across the US, EU, and Japan, highlighting China's rapid growth and investment in the industry.
The following are the leading companies in the separation systems for commercial biotechnology market. These companies collectively hold the largest market share and dictate industry trends.
This report forecasts revenue growth at country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2021 to 2033. For this study, Nova one advisor, Inc. has segmented the Separation Systems For Commercial Biotechnology market.
By Method
By Application
By Region
Chapter 1. Methodology and Scope
1.1. Market Segmentation and Scope
1.2. Market Definitions
1.3. Research Methodology
1.3.1. Information Procurement
1.3.2. Information or Data Analysis
1.3.3. Market Formulation & Data Visualization
1.3.4. Data Validation & Publishing
1.4. Research Scope and Assumptions
1.4.1. List of Data Sources
Chapter 2. Executive Summary
2.1. Market Outlook
2.2. Segment Outlook
2.3. Competitive Insights
Chapter 3. Separation Systems for Commercial Biotechnology Market Variables, Trends, & Scope
3.1. Market Introduction/Lineage Outlook
3.2. Market Size and Growth Prospects (USD Million)
3.3. Market Dynamics
3.3.1. Market Drivers Analysis
3.3.2. Market Restraints Analysis
3.4. Separation Systems for Commercial Biotechnology Market Analysis Tools
3.4.1. Porter’s Analysis
3.4.1.1. Bargaining power of the suppliers
3.4.1.2. Bargaining power of the buyers
3.4.1.3. Threats of substitution
3.4.1.4. Threats from new entrants
3.4.1.5. Competitive rivalry
3.4.2. PESTEL Analysis
3.4.2.1. Political landscape
3.4.2.2. Economic and Social landscape
3.4.2.3. Technological landscape
3.4.2.4. Environmental landscape
3.4.2.5. Legal landscape
Chapter 4. Separation Systems for Commercial Biotechnology Market: Method Estimates & Trend Analysis
4.1. Segment Dashboard
4.2. Separation Systems for Commercial Biotechnology Market: Method Movement Analysis, 2024 & 2033 (USD Million)
4.3. Conventional Methods
4.3.1. Conventional Methods Market Revenue Estimates and Forecasts, 2021 - 2033 (USD Million)
4.3.2. Chromatography
4.3.2.1. Chromatography Market Revenue Estimates and Forecasts, 2021 - 2033 (USD Million)
4.3.3. Flow Cytometry
4.3.3.1. Flow Cytometry Market Revenue Estimates and Forecasts, 2021 - 2033 (USD Million)
4.3.4. Membrane Filtration
4.3.4.1. Membrane Filtration Market Revenue Estimates and Forecasts, 2021 - 2033 (USD Million)
4.3.5. Electrophoresis
4.3.5.1. Electrophoresis Market Revenue Estimates and Forecasts, 2021 - 2033 (USD Million)
4.3.6. Centrifugation
4.3.6.1. Centrifugation Market Revenue Estimates and Forecasts, 2021 - 2033 (USD Million)
4.4. Modern Methods
4.4.1. Modern Methods Market Revenue Estimates and Forecasts, 2021 - 2033 (USD Million)
4.4.2. Microarray
4.4.2.1. Microarray Market Revenue Estimates and Forecasts, 2021 - 2033 (USD Million)
4.4.3. Lab-on-a-chip
4.4.3.1. Lab-on-a-chip Market Revenue Estimates and Forecasts, 2021 - 2033 (USD Million)
4.4.4. Magnetic Separation
4.4.4.1. Magnetic Separation Market Revenue Estimates and Forecasts, 2021 - 2033 (USD Million)
4.4.5. Biochip
4.4.5.1. Biochip Market Revenue Estimates and Forecasts, 2021 - 2033 (USD Million)
Chapter 5. Separation Systems for Commercial Biotechnology Market: Application Estimates & Trend Analysis
5.1. Segment Dashboard
5.2. Separation Systems for Commercial Biotechnology Market: Application Movement Analysis, 2024 & 2033 (USD Million)
5.3. Pharmaceutical
5.3.1. Pharmaceutical Market Revenue Estimates and Forecasts, 2021 - 2033 (USD Million)
5.3.2. Vaccines
5.3.2.1. Vaccines Market Revenue Estimates and Forecasts, 2021 - 2033 (USD Million)
5.3.3. Proteins
5.3.3.1. Proteins Market Revenue Estimates and Forecasts, 2021 - 2033 (USD Million)
5.3.4. Hormones/Insulin
5.3.4.1. Hormones/Insulin Market Revenue Estimates and Forecasts, 2021 - 2033 (USD Million)
5.3.5. Enzymes
5.3.5.1. Enzymes Market Revenue Estimates and Forecasts, 2021 - 2033 (USD Million)
5.3.6. Human Blood Plasma Fractionation
5.3.6.1. Human Blood Plasma Fractionation Market Revenue Estimates and Forecasts, 2021 - 2033 (USD Million)
5.3.7. Mammalian Cell Cultures
5.3.7.1. Mammalian Cell Cultures Market Revenue Estimates and Forecasts, 2021 - 2033 (USD Million)
5.4. Food & Cosmetics
5.4.1. Food & Cosmetics Market Revenue Estimates and Forecasts, 2021 - 2033 (USD Million)
5.5. Agriculture
5.5.1. Agriculture Market Revenue Estimates and Forecasts, 2021 - 2033 (USD Million)
5.6. Others
5.6.1. Others Market Revenue Estimates and Forecasts, 2021 - 2033 (USD Million)
Chapter 6. Separation Systems for Commercial Biotechnology Market: Regional Estimates & Trend Analysis
6.1. Separation Systems for Commercial Biotechnology Market Share, By Region, 2024 & 2033 (USD Million)
6.2. North America
6.2.1. North America Separation Systems for Commercial Biotechnology Market Estimates and Forecasts, 2021 - 2033 (USD Million)
6.2.2. U.S.
6.2.2.1. U.S. Separation Systems for Commercial Biotechnology Market Estimates and Forecasts, 2021 - 2033 (USD Million)
6.2.3. Canada
6.2.3.1. Canada Separation Systems for Commercial Biotechnology Market Estimates and Forecasts, 2021 - 2033 (USD Million)
6.2.4. Mexico
6.2.4.1. Mexico Separation Systems for Commercial Biotechnology Market Estimates and Forecasts, 2021 - 2033 (USD Million)
6.3. Europe
6.3.1. Europe Separation Systems for Commercial Biotechnology Market Estimates and Forecasts, 2021 - 2033 (USD Million)
6.3.2. UK
6.3.2.1. UK Separation Systems for Commercial Biotechnology Market Estimates and Forecasts, 2021 - 2033 (USD Million)
6.3.3. Germany
6.3.3.1. Germany Separation Systems for Commercial Biotechnology Market Estimates and Forecasts, 2021 - 2033 (USD Million)
6.3.4. France
6.3.4.1. France Separation Systems for Commercial Biotechnology Market Estimates and Forecasts, 2021 - 2033 (USD Million)
6.3.5. Italy
6.3.5.1. Italy Separation Systems for Commercial Biotechnology Market Estimates and Forecasts, 2021 - 2033 (USD Million)
6.3.6. Spain
6.3.6.1. Spain Separation Systems for Commercial Biotechnology Market Estimates and Forecasts, 2021 - 2033 (USD Million)
6.3.7. Denmark
6.3.7.1. Denmark Separation Systems for Commercial Biotechnology Market Estimates and Forecasts, 2021 - 2033 (USD Million)
6.3.8. Sweden
6.3.8.1. Sweden Separation Systems for Commercial Biotechnology Market Estimates and Forecasts, 2021 - 2033 (USD Million)
6.3.9. Norway
6.3.9.1. Norway Separation Systems for Commercial Biotechnology Market Estimates and Forecasts, 2021 - 2033 (USD Million)
6.4. Asia Pacific
6.4.1. Asia Pacific Separation Systems for Commercial Biotechnology Market Estimates and Forecasts, 2021 - 2033 (USD Million)
6.4.2. Japan
6.4.2.1. Japan Separation Systems for Commercial Biotechnology Market Estimates and Forecasts, 2021 - 2033 (USD Million)
6.4.3. China
6.4.3.1. China Separation Systems for Commercial Biotechnology Market Estimates and Forecasts, 2021 - 2033 (USD Million)
6.4.4. India
6.4.4.1. India Separation Systems for Commercial Biotechnology Market Estimates and Forecasts, 2021 - 2033 (USD Million)
6.4.5. Australia
6.4.5.1. Australia Separation Systems for Commercial Biotechnology Market Estimates and Forecasts, 2021 - 2033 (USD Million)
6.4.6. South Korea
6.4.6.1. South Korea Separation Systems for Commercial Biotechnology Market Estimates and Forecasts, 2021 - 2033 (USD Million)
6.4.7. Thailand
6.4.7.1. Thailand Separation Systems for Commercial Biotechnology Market Estimates and Forecasts, 2021 - 2033 (USD Million)
6.5. Latin America
6.5.1. Latin America Separation Systems for Commercial Biotechnology Market Estimates and Forecasts, 2021 - 2033 (USD Million)
6.5.2. Brazil
6.5.2.1. Brazil Separation Systems for Commercial Biotechnology Market Estimates and Forecasts, 2021 - 2033 (USD Million)
6.5.3. Argentina
6.5.3.1. Argentina Separation Systems for Commercial Biotechnology Market Estimates and Forecasts, 2021 - 2033 (USD Million)
6.6. Middle East and Africa
6.6.1. Middle East and Africa Separation Systems for Commercial Biotechnology Market Estimates and Forecasts, 2021 - 2033 (USD Million)
6.6.2. South Africa
6.6.2.1. South Africa Separation Systems for Commercial Biotechnology Market Estimates and Forecasts, 2021 - 2033 (USD Million)
6.6.3. Saudi Arabia
6.6.3.1. Saudi Arabia Separation Systems for Commercial Biotechnology Market Estimates and Forecasts, 2021 - 2033 (USD Million)
6.6.4. UAE
6.6.4.1. UAE Separation Systems for Commercial Biotechnology Market Estimates and Forecasts, 2021 - 2033 (USD Million)
6.6.5. Kuwait
6.6.5.1. Kuwait Separation Systems for Commercial Biotechnology Market Estimates and Forecasts, 2021 - 2033 (USD Million)
Chapter 7. Competitive Landscape
7.1. Recent Developments & Impact Analysis by Key Market Participants
7.2. Company Categorization
7.3. Company Heat Map Analysis
7.4. Company Profiles
7.4.1. Thermo Fisher Scientific Inc.
7.4.1.1. Participant’s Overview
7.4.1.2. Financial Performance
7.4.1.3. Product Benchmarking
7.4.1.4. Recent Developments/Strategic Initiatives
7.4.2. QIAGEN
7.4.2.1. Participant’s Overview
7.4.2.2. Financial Performance
7.4.2.3. Product Benchmarking
7.4.2.4. Recent Developments/Strategic Initiatives
7.4.3. Horizon Discovery Ltd.
7.4.3.1. Participant’s Overview
7.4.3.2. Financial Performance
7.4.3.3. Product Benchmarking
7.4.3.4. Recent Developments/Strategic Initiatives
7.4.4. OriGene Technologies, Inc.
7.4.4.1. Participant’s Overview
7.4.4.2. Financial Performance
7.4.4.3. Product Benchmarking
7.4.4.4. Recent Developments/Strategic Initiatives
7.4.5. Oxford Biomedica PLC
7.4.5.1. Participant’s Overview
7.4.5.2. Financial Performance
7.4.5.3. Product Benchmarking
7.4.5.4. Recent Developments/Strategic Initiatives
7.4.6. SignaGen Laboratories
7.4.6.1. Participant’s Overview
7.4.6.2. Financial Performance
7.4.6.3. Product Benchmarking
7.4.6.4. Recent Developments/Strategic Initiatives
7.4.7. Flash Therapeutics
7.4.7.1. Participant’s Overview
7.4.7.2. Financial Performance
7.4.7.3. Product Benchmarking
7.4.7.4. Recent Developments/Strategic Initiatives
7.4.8. Takara Bio Inc.
7.4.8.1. Participant’s Overview
7.4.8.2. Financial Performance
7.4.8.3. Product Benchmarking
7.4.8.4. Recent Developments/Strategic Initiatives
7.4.9. Bio-Rad Laboratories, Inc.
7.4.9.1. Participant’s Overview
7.4.9.2. Financial Performance
7.4.9.3. Product Benchmarking
7.4.9.4. Recent Developments/Strategic Initiatives
7.4.10. System Biosciences, LLC.
7.4.10.1. Participant’s Overview
7.4.10.2. Financial Performance
7.4.10.3. Product Benchmarking
7.4.10.4. Recent Developments/Strategic Initiatives
7.4.11. Promega Corporation
7.4.11.1. Participant’s Overview
7.4.11.2. Financial Performance
7.4.11.3. Product Benchmarking
7.4.11.4. Recent Developments/Strategic Initiatives
7.4.12. F. Hoffmann-La Roche Ltd
7.4.12.1. Participant’s Overview
7.4.12.2. Financial Performance
7.4.12.3. Product Benchmarking
7.4.12.4. Recent Developments/Strategic Initiatives
7.4.13. Revvity
7.4.13.1. Participant’s Overview
7.4.13.2. Financial Performance
7.4.13.3. Product Benchmarking
7.4.13.4. Recent Developments/Strategic Initiatives
7.4.14. Catalent, Inc
7.4.14.1. Participant’s Overview
7.4.14.2. Financial Performance
7.4.14.3. Product Benchmarking
7.4.14.4. Recent Developments/Strategic Initiatives
Cross-segment Market Size and Analysis for Mentioned Segments
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Additional Countries (Apart
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Country/Region-specific Report
Go To Market Strategy
Region Specific Market DynamicsRegion Level Market Share Import Export AnalysisProduction AnalysisOthers