U.S. Research Antibodies Market Size, Share & Trends Analysis Report By Product, By Specificity (Monoclonal, Polyclonal), By Technology, By Source, By Application, By End-use, And Segment - Industry Analysis, Share, Growth, Regional Outlook and Forecasts, 2024-2033

The U.S. research antibodies market size was estimated at USD 609.19 million in 2023 and is projected to hit around USD 910.46 million by 2033, growing at a CAGR of 4.1% during the forecast period from 2024 to 2033.

Key Takeaways:

• Primary antibodies held the dominant share of the market in 2023, accounting for over 70.9% of the revenue generated, and are anticipated to grow at the fastest CAGR over the forecast period.
• Secondary antibodies are anticipated to register significant growth from 2024 to 2033.
• Monoclonal antibodies led the market in 2023 with 60.9% of the total revenue share
• On the contrary, polyclonal antibodies are anticipated to grow at a significant rate owing
• Western blotting was the dominant technology used in the market in 2023 with 30.5% of the total revenue share.
• The immunohistochemistry (IHC) segment is expected to register the fastest CAGR during the forecast period.
• Rabbits generated over 50.8% of the total revenue share in 2023
• Mice are expected to grow the fastest from 2024 to 2033
• Oncology held the most substantial share of the application segment in 2023, accounting for 34.9% of the total market revenue.
• Infectious diseases are expected to have the fastest CAGR over the forecast period.
• Academic & research applications occupied the largest revenue share in the market of nearly 61.7% in 2023 and are expected to grow at the fastest CAGR over the forecast period.
• The pharma and biotech companies segment is anticipated to grow significantly from 2024 to 2033

U.S. Research Antibodies Market Growth

The steady rise in research and development (R&D) activities, led by biopharmaceutical and pharmaceutical companies and paired with increased public-private investments in R&D, are expected to boost demand for research antibodies, thus contributing to market growth.

The U.S. research antibodies market led the global research antibodies market in 2023, accounting for over 30% of the revenue share generated, owing to several factors such as the increasing use of these complex products in research & academic institutions, as well as major pharmaceutical and biotechnology companies.

A significant factor contributing to the high market share is the growing focus on biomedical, stem cell, and cancer research. The increasing prevalence of chronic diseases, such as cardiovascular and blood disorders, is expected to further fuel market growth. As per the American Cancer Society’s 2021 Cancer Facts & Figures, an estimated 1.9 million new cancer cases and over 608,570 cancer deaths were projected to occur in the country in 2021, with a heightened emphasis on cancer research and stem cell research activities.

Stem cell therapy has emerged as a promising technique for treating severe medical conditions, including cancer and blood diseases. Consequently, biotechnology and biopharmaceutical companies are increasingly adopting advanced research antibodies for stem cell research. This trend is anticipated to drive the market significantly.

Investing in recombinant technology is crucial for scaling antibody production to meet researchers’ needs and addressing new issues as new host species are introduced in the future. For instance, ZooMAb recombinant monoclonal antibodies support researchers in the early stages of biopharmaceutical testing, enabling them to progress with downstream processes and allowing access to the highest-quality antibodies, opening up more opportunities for research in the country.

U.S. Research Antibodies Market Report Scope

Product Insights

Primary antibodies held the dominant share of the market in 2023, accounting for over 70.9% of the revenue generated, and are anticipated to grow at the fastest CAGR over the forecast period. This isprimarily attributable to the rising development of primary antibodies sourced from host species like rabbits, goats, mice, and others. Moreover, this growth can be credited to the diverse range of forms these antibodies are supplied in, catering to the varying research requirements. The frequent use of primary antibodies in targeting commonly researched biological components contributes to the segment’s expected exponential growth.

Secondary antibodies are anticipated to register significant growth from 2024 to 2033. These antibodies play a crucial role in facilitating tasks such as sorting, detecting, and purifying target antigens, thereby enhancing the overall efficiency of research activities. Another factor contributing to their increasing demand is the ease of development and cost-effectiveness of secondary antibodies. Furthermore, their availability in ready-to-use forms is expected to boost their popularity and usage in various research applications in the coming years.

Specificity Insights

Monoclonal antibodies led the market in 2023 with 60.9% of the total revenue share, owing to their high specificity for detection of antigens and efficient staining properties with less background noise. Moreover, the segment is expected to register the fastest growth over the forecast period, which is attributable to its potential to effectively bind to or inhibit antigens on cancer cells makes them valuable tools in the identification and development of novel cancer treatments for various types of cancer. This capability is likely to enhance the growth prospects for this segment in the foreseeable future.

On the contrary, polyclonal antibodies are anticipated to grow at a significant rate owing to ability to recognize multiple epitopes and possess greater tolerance to change in antigens. Polyclonal antibodies hold significant importance in histopathological tissue analysis and antigen purification. The growing awareness concerning cancer treatments and other diseases has led to increased demand for these antibodies. Compared to monoclonal antibodies, polyclonal antibodies are more cost-effective, which may boost their usage in low-budget and non-funded research projects. It is crucial to note that polyclonal antibodies may vary between batches due to manufacturing and quality control factors, and they can recognize multiple epitopes, potentially increasing the likelihood of non-specific antigen binding.

Technology Insights

Western blotting was the dominant technology used in the market in 2023 with 30.5% of the total revenue share. As of 2022, the Center for Disease Control and Prevention (CDC) reported that approximately 1.2 million Americans are living with HIV, with California accounting for the highest diagnoses in the country. The increasing prevalence of HIV in the country has led to a significant demand for antibodies in western blotting tests. Western blotting is preferred over ELISA tests for detecting HIV due to its higher accuracy in identifying HIV antibodies in patient blood samples.

The immunohistochemistry (IHC) segment is expected to register the fastest CAGR during the forecast period. Widely used in cancer diagnosis, IHC’s growth is driven by the consistent rise in cancer cases. It plays a significant role in tumor prognosis and has been increasingly incorporated. IHC identifies enzymes, antigens, tumor suppressor genes, and tumor cell proliferation, offering advantages over traditional staining techniques due to specific reactions. IHC’s adoption in clinical diagnostics and life science research is fueled by increased healthcare spending, improved infrastructure, and enhanced research facilities.

Source Insights

Rabbits generated over 50.8% of the total revenue share in 2023, dominating the market by a landslide. Rabbit antibodies’ extensive use in antibody production is due to their advantages, such as higher affinity and specificity compared to antisera from other animal hosts. This high specificity enables their application in detecting small molecules like pollutants, toxins, hormones, drugs, non-protein targets, and post-translational changes. In disease diagnosis, rabbit antibodies showcase enhanced immune response to small epitopes.

Mice are expected to grow the fastest from 2024 to 2033, as the growing use of murine monoclonal antibodies in research is driving overall market growth. Mice are preferred due to their structural similarities with human antibodies and cost-effectiveness. Their shorter lifespan makes them suitable for aging and drug efficacy studies. Mice are vital in complex disease research, such as hypertension and atherosclerosis. The increasing prevalence of cancer and Alzheimer’s disease has led to higher demand for mouse monoclonal antibodies as research reagents.

Application Insights

Oncology held the most substantial share of the application segment in 2023, accounting for 34.9% of the total market revenue. Research antibodies are vital in targeted cancer therapy, revolutionizing treatment by specifically binding to cancer cell antigens. This precision allows for selectively targeting and destroying cancer cells while preserving healthy tissues. The FDA’s growing approvals of monoclonal antibodies for specific biomarkers have significantly boosted their usage in oncology, making them a foundation of modern cancer therapy.

Infectious diseases are expected to have the fastest CAGR over the forecast period. The increasing prevalence of infectious diseases, an aging population, and growing awareness about communicable diseases have emerged as significant drivers for the growth of the diagnostic devices market. Consequently, the market is experiencing higher demand for rapid diagnostic tools such as point-of-care tests for qualitative analysis of infections, enabling timely preventive measures.

End-use Insights

Academic & research applications occupied the largest revenue share in the market of nearly 61.7% in 2023 and are expected to grow at the fastest CAGR over the forecast period. Academic research applications are expected to experience continuous expansion due to the involvement of diverse academic research groups studying intricate biological systems with advanced reagents. This trend will offer the segment significant growth prospects, leading to a deeper comprehension of biological processes and complex systems.

The pharma and biotech companies segment is anticipated to grow significantly from 2024 to 2033, owing to the increased use of assays in the pharmaceutical and biotechnological companies. This heightened demand is fueled by the rising prevalence of conditions like cancer and autoimmune diseases such as Type 1 Diabetes, necessitating antibodies for treatment and diagnostics. Antibodies, alongside other consumables, play a vital role in the treatment and development processes within these industries. The market is further boosted by the growing R&D activities in pharmaceutical and biotechnology sectors.

Recent Developments

• In March 2024, Rapid Novor and MAbSilico collaborated to introduce the first AI-guided epitope mapping service for antibodies using HDX-MS technology, combining computational modeling with experimental data to enhance antibody structure analysis.
• In January 2024, Johnson & Johnson acquired Ambrx Biopharma, a clinical-stage biopharmaceutical company with a proprietary synthetic biology technology platform. This acquisition allowed Johnson & Johnson to strengthen its oncology therapeutics portfolio and accelerate the development of next-generation ADCs.
• In August 2023, ERS Genomics granted Santa Cruz Biotechnology, a U.S.-based global leader in biomedical research, access to its CRISPR/Cas9 patent portfolio through a new license agreement. This collaboration leveraged ERS’s comprehensive gene editing technology rights, enhancing Santa Cruz Biotechnology’s position in the research antibodies market with innovative CRISPR products, bolstering scientific advancements.
• In August 2023, Regeneron partnered with BARDA to develop a novel monoclonal antibody therapy for COVID-19 prevention, receiving partial funding under ‘Project NextGen.’
• In February 2023, Roche introduced two new antibodies, IDH1 R132H and ATRX, to identify key mutations in brain cancer patients. These additions to Roche’s neuropathology portfolio, which comprise 29 biomarkers, enhanced the understanding of brain tumor molecular alterations and aid in personalized patient care.

Key U.S. Research Antibodies Company Insights

The U.S. research antibodies market is moderately consolidated and highly competitive due to low entry barriers. The observed growth in this particular sector can be attributed to the implementation of comprehensive expansion strategies, new product development, geographical expansions, and mergers & acquisitions. Companies in the U.S. research antibodies market have been proactive in adopting such strategies to enhance their market presence and drive growth.

For instance, in December 2023, C4 Therapeutics partnered with Merck to develop degrader-antibody conjugates for cancer treatment. This collaboration aimed to combine degraders’ efficiency with antibodies’ specificity. Some companies in the U.S. research antibodies market include Abcam Plc.; Merck KGaA; Thermo Fisher Scientific, Inc.; Cell Signalling Technology, Inc.; Santa Cruz Biotechnology Inc.; and PerkinElmer, Inc.

Key U.S. Research Antibodies Companies:

• Abcam Plc.
• Merck KGaA
• Thermo Fisher Scientific, Inc.
• Cell Signalling Technology, Inc.
• Santa Cruz Biotechnology Inc.
• PerkinElmer, Inc.
• Becton, Dickinson and Company
• Bio-Techne Corporation
• Proteintech Group, Inc.
• Jackson ImmunoResearch Inc.

Segments Covered in the Report

This report forecasts revenue growth at country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2021 to 2033. For this study, Nova one advisor, Inc. has segmented the U.S. Research Antibodies market.

By Product 

• Primary
• Secondary

By Specificity 

• Monoclonal Antibodies
• Polyclonal Antibodies

By Technology 

• Immunohistochemistry
• Immunofluorescence
• Western Blotting
• Flow Cytometry
• Immunoprecipitation
• ELISA
• Other Technologies

By Source 

• Mice
• Rabbit
• Goat
• Other Sources

By Application 

• Infectious Diseases
• Immunology
• Oncology
• Stem Cells
• Neurobiology
• Other Applications

By End-use 

• Academic & Research Institutes
• Contract Research Organizations
• Pharma & Biotech Companies